ATL146e treatment decreases pulmonary injury during hypoxia-reoxygenation (H-R) of NY1DD mice. NY1DD mice were subjected to 3 hours of hypoxia (8% oxygen) and 18 hours of reoxygenation. Lungs were then removed, inflation-fixed, and stained with H&E or immunostained for neutrophils. Three hours after reoxygenation, mice were implanted with Alzet minipumps containing either vehicle (A) or ATL146e (10 ng/kg/minute; B). The sections shown are typical of 4 replicates. Bars, 200 μm.