Effect of ONX 0912 on apoptosis, neovascularization, and ubiquitination in vivo in xenografted MM tumors. (A-D) Human bone chips were removed from mice after the last treatment and immunostained with Abs against Caspase-3, Factor VIII, VEGFR1, and Ubiquitin. Scale bar, 10μm. Dark brown represents marker-positive cells in all cases. Micrographs are representative of bone sections from 2 different mice in each group. (E) Mice in vehicle-treated control and ONX 0912–treated groups were weighed every week. The average changes in body weight are shown.