Different expression patterns of CD57 and effector-memory marker on HIV-specific clonotypes. Relative distribution of CD57⁺ (A) and TemRA-phenotype cells (B) between dominant (most frequent) clonotypes and subdominant (less frequent) clonotypes within HIV-epitope–specific CD8⁺ T-cell responses. (C) Relationship of CD57⁺ expression on the same clonotype expressing either TemRO or TemRA phenotype marker.