AICAR induces apoptosis independently of TP53 or ATM in CLL cells. (A) Cells with mutated TP53 (patients 24 and 25) or with 17p13 deletion (patients 26 and 27) were untreated (□) or treated with 0.5mM AICAR (■) for 24 and 48 hours. (B) Cells with 11q23 deletion and without ATM protein (patient 7 and 28) were untreated (□) or treated with 0.5mM (▩) and 1mM (■) AICAR for 24 and 48 hours. Viability was measured by flow cytometry, and it is expressed as the percentage of the viability (A-B).