GPS is a progressive disorder. (A) Platelet counts of 14 GPS patients plotted against their age showing a significant negative correlation (y = -42.04 ln(x) + 174.14, R2 = 0.805). Patient 13(II-1), who had splenectomy, is not included. (B) Bone marrow of patient 8 (II-1) at age 10 showing mild (grade 1) reticulin fibrosis (arrows). (C) Bone marrow of patient 8 (II-1) at age 29 showing grade 2–3 reticulin fibrosis (arrows). (D) Bone marrow of patient 13(II-1) at age 47 showing grade 3 reticulin fibrosis (arrows). (E) Bone marrow of patient 4(IV-2) showing grade 3 reticulin fibrosis (arrows). Olympus BX-51 microscope (Olympus America, Melville, NY) equipped with a UPlanFL 20×/0.50 numeric aperture objective. Images were captured using an Olympus DP70 digital camera system. Imaging software was Adobe Photoshop CS3 (Adobe Systems); magnification 200×, all images.
