The endogenous angiogenesis inhibitor, PEDF, acts via NF-κB signaling to induce apoptosis of endothelial cells. NF-κB upregulates proapoptotic FasL expression by recruiting p300 HAT, causing histone acetylation. It also down-regulates prosurvival cFLIP by displacing NFAT and recruiting HDAC, causing histone deacetylation.