Figure 7
Figure 7. CD8+ T cells relieve 34-1-2 mAb-induced hypothermia in SCID mice. Rectal temperatures over time (minutes) in control mice receiving nothing (●, N = 10) or SCID mice injected with 2.3 mg/kg 34-1-2s alone (○, N = 20) or SCID mice receiving antibody and a transfer of 2 × 107 purified CD8+ T cells (▵, N = 6), CD4+ T cells (▿, N = 7), purified CD19+ B cells (◊, N = 6), or splenocytes depleted of both CD4+ and CD8+ T cells (▴, N = 6). Temperatures in BALB/c mice receiving only antibody (□, N = 21) are also shown.

CD8+ T cells relieve 34-1-2 mAb-induced hypothermia in SCID mice. Rectal temperatures over time (minutes) in control mice receiving nothing (●, N = 10) or SCID mice injected with 2.3 mg/kg 34-1-2s alone (○, N = 20) or SCID mice receiving antibody and a transfer of 2 × 107 purified CD8+ T cells (▵, N = 6), CD4+ T cells (▿, N = 7), purified CD19+ B cells (◊, N = 6), or splenocytes depleted of both CD4+ and CD8+ T cells (▴, N = 6). Temperatures in BALB/c mice receiving only antibody (□, N = 21) are also shown.

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