34-1-2s induced severe hypothermia in SCID mice. Rectal temperatures over time in (A) BALB/c mice and (B) SCID mice either not injected (naive, ●) or injected with 2.3 mg/kg (○), 4.5 mg/kg (□), 9.1 mg/kg (◊), or 22.7 mg/kg (▵) of 34-1-2s mAb. There were 5 to 25 mice per group. Data are mean ± SD temperatures.