VavP-Mcl-1 mice die of lymphoma. (A) Kaplan-Meier survival curve of tumor-related deaths in cohorts of the following mice: WT (black, n = 54); Mcl-1(33) (red, n = 23), median survival, 531 days; Mcl-1(8) (green, n = 29), median survival, 571 days; Mcl-1(37) (orange, n = 18), median survival, 556 days; and Mcl-1(4) (blue, n = 38), median survival, 612 days. (B) Immunophenotype of representative stem/progenitor cell tumor (from transgenic mouse Mcl-1(33) #90). (C-D) Representative histology from VavP-Mcl-1 mouse dying of primitive/progenitor cell tumor showing infiltration of (C) liver and (D) lung. (E-F) Representative histology from VavP-Mcl-1 mouse dying of pre-B cell tumor showing infiltration of (E) liver and (F) lung. (G-H) Representative histology from VavP-Mcl-1/Eμ-Myc mouse dying of B-cell tumor showing infiltration of (G) liver and (H) lung. Sections were stained with hematoxylin and eosin. Original magnification ×20 in main panels. Sections were photographed on Kodak Ektachrome 64T film using a Zeiss Axiophot microscope and camera with a Zeiss 20×/0.60 NA objective lens. The scanned images were processed using Adobe Photoshop software.