The correlation between the Th17 marrow-derived cytokine profile and lytic bone disease in myeloma patients. (A) MIP-1α, TGF-β, IL-6, IL-1β, IL-23, and IL-17 levels were determined by ELISA on myeloma BM plasma. The correlation between cytokine levels and the extent of bone disease is graphed (n = 40). Values are plotted on a log2 scale. (B) Clinical parameters and bone disease. Serum calcium, alkaline phosphatase, and the percentage plasma cells in the BM were graphed in relation to the extent of bone disease in the patients (n = 40).