Locations of patient regulatory domain mutations in the autoinhibited conformations of ABL. The crystal structure of autoinhibited ABL in complex with the kinase inhibitor PD166326 (PDB entry 2FO0)¹²  displayed with the locations of the mutated residue side chains shown in green stick format. The mutations are dispersed across the SH2 (green), SH3 (yellow), and linker domains (red, magenta). Stick format atoms are color-coded for nitrogen (dark blue), oxygen (red), and sulfur (orange). The figure was created using PyMol.²²