Neurogenic inflammation occurs in SCA. (A-B) Evans blue leakage evoked by injection of saline, capsaicin, or SP in the hind paws (A) and dorsal skin (B) of mice treated with vehicle (saline), morphine sulfate (MS, 10 mg/kg), CS (100 mg/kg), or imatinib (Imat, 100 mg/kg). (C-D) Evans blue leakage. *P < .05, **P < .01 vs HbSS-BERK Veh, #P < .05, ##P < .01 vs HbAA-BERK Veh (ANOVA with Bonferroni). (E) Measures of cutaneous blood flow. **P < .01 (Student t test). (F) Temperature of the dorsal skin of mice with representative thermogram. *P < .05 (Student t test). (G) Calibration bar used.