Activation of the Wnt pathway in CLL cells and not in normal mature B cells. (A) TCF/LEF dual luciferase reporter assay relative fold change of positive reporter samples from 6 unmutated CLL samples, 10 mutated CLL samples, and 3 normal B-cell samples. *P = .024. **P = .014. Horizontal lines indicate the mean of the group. (B) Western blot analysis of β-catenin in 6 CLL and 2 normal B-cell samples. β-Actin shown as a loading control of samples.