RH genotype of the patient with sickle cell disease. The common RH haplotype Dce is represented by the RHD and RHCE genes, which are homologous, oriented in opposite directions, and comprise 10 exons each (top panel). The patient's genotype harbors the variant (C)ce^s type 1 and the common dce haplotypes (bottom panel). The variant amino acid substitutions are shown by positions and amino acids involved, relative to the common RH alleles.