Treatment with an antioxidant prevents the bone loss induced by iron overload. (A) Micro-CT analysis of mice treated with placebo, iron dextran alone, or iron dextran plus NAC for 2 months: placebo (▭), iron dextran (▬), and iron + NAC (). Data are mean ± SD. NS indicates not significant. *P < .01. (B) Micro-CT images of placebo, iron dextran, and iron dextran + NAC animals. Trabecular bone at distal femur and cortical bone at mid-diaphysis femur.