Iron-overloaded mice exhibit osteoporosis. (A) Liver, spleen, and femur iron contents increased in iron dextran-treated animals (▬) compared with controls (▭). Note the change in scale. Data are mean ± SD. *P < .01. (B) Micro-CT images of iron-overloaded animals and their placebo controls: femoral sections showing thinning of trabecular bone, with mid-diaphysis femur demonstrating thinning of the cortical bone and increased marrow area.