Results from NSG mice transplanted with human cells expressing BCR/FGFR1 or ZMYM2/FGFR1. (A) BCR/FGFR1 mice all died at day 32 or earlier, whereas ZMYM2/FGFR1 mice survived longer. All MIG control mice, and 3 ZMYM2/FGFR1 mice survived until end of study. (B) The engraftment of human cells was on average 70% in BCR/FGFR1 mice, 74% in ZMYM2/FGFR1 mice, and 78% in MIG control mice at end of life (23-65 days). Error bars represents SEM. (C) The percentage of human myeloid (CD33/15⁺) cells was significantly higher in BCR/FGFR1 mice (black), but not in ZMYM2/FGFR1 mice (gray), compared with MIG control mice (white). The erythroid cell lineage (CD235a⁺) was pronounced in both BCR/FGFR1 mice and ZMYM2/FGFR1 mice. Data are presented as the mean value of all analyzed mice with error bars representing SEM.