Clinical outcome stratified by IDH1 mutant status. Kaplan-Meier curves for (A) cumulative incidence of relapse and (B) overall survival in the total cohort. (C) Mantel-Byar analysis for the effect of IDH1 mutations on relapse risk stratified by NPM1, FLT3/ITD, and FLT3/TKD mutant status. (D) Cumulative incidence of relapse by IDH1 status in FLT3/ITD-WT and (E) FLT3/ITD-mutant patients. WT indicates wild-type; CR, complete remission; O-E, observed minus expected; Var., variance; O.R., odds ratio; CI, confidence interval; and NS, not significant.