The effect of mutation analyses at either diagnosis or relapse on overall survival. Kaplan-Meier estimates of overall survival for patients with mutated and wild-type FLT3/ITD, patients with mutated and wild-type RAS, and patients with mutated and wild-type WT1. Lines represent wild-type patients, dashed lines mutated patients. Left plots show estimates with the use of initial diagnosis analyses, right plots are from relapse analyses.