Increased expression of type I IFN-regulated proteins in patients with a history of VD. Patients with vascular disease (VD+), myocardial infarction (MI), venous thrombosis (Ven.+), and arterial thrombosis (Art.+) are compared with patients without VD (VD−). Patients with a history of aCL antibodies (aCL+) are compared with patients without a history of aCL antibodies (aCL−) and patients with antiphospholipid antibody syndrome (APS+) are compared with patients without APS (APS−). Healthy controls (HC) are also included. The lines represent the median-values. The statistical significance is noted above each set of data where * indicates P < .05; **, P < .01; and ***, P < .001.