Hematologic parameters indicate acute thrombocytopenia and intravascular hemolysis after inhibition of ADAMTS13. (A-D) Hematologic parameters were determined in blood samples from subject (●, n = 6) or control animals (■, n = 5), and mean values ± SD are shown. (A) Subject animals were thrombocytopenic from 24 hours onwards, dropping further to less than 12 × 109/L at 48 hours. (B) In subject animals, haptoglobin levels fell below the detection limit from 72 hours onwards. Regular statistics could no longer be performed (ND) for these time points. (C) Hemoglobin levels were significantly lower in the subject group from 72 hours onwards. (D) Total serum LDH activity increased significantly at 48 hours, indicating organ and erythrocyte damage. Arrows indicate time points of injection.
