Reconstitution of plasma HRG improves survival after bacterial challenge of HRG-deficient animals. Wild-type (n = 11) or HRG-deficient animals (n = 9) were infected with S pyogenes (1 × 10⁷ CFU/animal) by subcutaneous injection. One group of HRG-deficient animals (n = 10) received an intraperitoneal injection of purified HRG (500 μg/animal) at the same time point as bacteria and again at 24 hours after infection. The percentage survival per group is represented in a Kaplan-Meier survival curve.