HRG-deficient animals have significantly increased mortality in response to S pyogenes infection. S pyogenes (1 × 10⁷ CFU) was administered by subcutaneous injection to wild-type (full lines) or HRG-deficient animals (dashed lines) (n = 15 per group). (A) The surviving animals were weighed on a daily basis, and the percentage weight loss was calculated for each animal. Data are mean ± SEM; n = 14: * (Left) P = .01 and * (Right) P = .03, respectively. (B) The percentage survival per group was determined on a daily basis and is represented in a Kaplan-Meier survival curve.