NFκB index and regulators of NFκB activity. (A) NFκB index determined by Annunziata et al³¹  on the basis of the mean expression of 11 genes (BIRC3, TNFAIP3, NFKB2, IL2RG, NFKBIE, RELB, NFKBIA, CD74, PLEK, MALT1, WNT10A). (B) NFκB index determined by Keats et al³²  on the basis of the mean expression of 4 genes (CD74, IL2RG, and TNFAIP3, 2×). Expression (log2) per cluster of negative regulators of the NFκB pathway: (C) TRAF3 and (D) CYLD. Expression (log2) of positive regulators of NFκB pathway: (E) CD40 and (F) NIK.