Effect of bifunctional A11-plasminogen Kringle (SLK) on reinitiation of carotid artery flow after 4 hours of thrombus inhibition of blood flow. Intravenous infusion of A11 (25 μg/mouse) had no effect; n = 4 (SEM). SLK (37.5 μg/mouse) restored blood flow after 4 hours of cessation of blood flow; n = 3 (SEM). P < .001 for treatment effect, by 2-way ANOVA. Post hoc Bonferroni testing indicated P < .05 at 35 minutes, P < .01 at 40 to 50 minutes, and P < .001 from 55 minutes to 19 hours. * indicates the time point from which the SLK-treated mice were statistically different from controls by post-hoc testing.