Ligation of GPIIIa49-66 with A11 reconstitutes blocked carotid artery thrombus blood flow 2 hours after cessation of blood flow. The carotid artery of mouse was dissected free of surrounding tissue and a FeCI₃ patch applied for 20 minutes, followed by rinsing. Blood flow was monitored with a Doppler flow apparatus. Cessation of blood flow was generally at 35 minutes. Two hours after cessation of blood flow (vertical lines), the mice were infused intravenously with 25 μg of A11 or 20 μg of control scFv Ab (Ctl). Note the rapid reonset of blood flow, 10 to 15 minutes after infusion. P < .001 by 2-way ANOVA for treatment effect. By post hoc Bonferroni testing at 35 to 45 minutes, P < .01, A11 (n = 4) versus control scFv Ab (n = 5). For time points between 50 and 1140 minutes, P < .001, A11 (n = 4) versus control scFv Ab (n = 5).