Effect of A11 on inhibition of FeCI₃ induced carotid artery platelet thrombus formation. Swiss-Webster mice were injected intravenously with 25 μg of scFv A11 or irrelevant control scFv Ab (13CG2). The right carotid artery was exposed and a FeCI₃ filter paper patch applied 2 hours after intravenously injection and removed at 20 minutes. Blood flow (recording in arbitrary perfusion units, pfu) was measured with a Doppler flow meter. (A) Mean continuous blood flow measured in 5 controls and 6 experimental A11 mice over a period of 38 to 43 minutes, respectively. (B) The same experiment with SEM given every 5 minutes as well as a single saline control experiment (SAL). *Statistically significant differences (P < .01) by post hoc Bonferroni testing scFv A11 versus either saline control (Sal) or control scFv Ab 13CG2 (Ctl) at 25, 30, and 35 minutes; n = 5 or 6 per group (SEM).