Figure 5
![Figure 5. Role of AMPKα2 in the phosphorylation of β3 integrin. (A) Effect of AMPK inhibition (compound C [Comp C], 10μM) on the thrombin-induced phosphorylation (p-Tyr747) of β3 integrin in washed human platelets. (B) Thrombin-induced phosphorylation of β3 integrin in platelets from AMPKα2+/+, α2−/−, α1+/+, and α1−/− mice. The bar graphs summarize data from 6 different experiments; *P < .05 and **P < .01 vs solvent (Sol)–treated platelets.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/116/12/10.1182_blood-2010-04-279612/4/zh89991057640005.jpeg?Expires=1722434878&Signature=WFrWVii-tmVqbKMZ1g365CiE0dVxZWAt6Chh7SYYLfuL-MgcCeEwwDeJudnxx2fjveYAnUxGPzRCMowgRUG6lmRaVakEBJqb~iQQs3XZpMoucb9miLmTyf-7cC1BxKY5TXCzZwnoYrzzKZXZXyu0mKzeKnuZOJlOjg8QNUcQNNsc8uyn0X~N1GnrlbS3lPujwiXp7klM5uywmRZkYu-~V8pmP682IHPjuHEdGJ7WyEh1UmGO3rk28XqqOi1B0ieYE7xPqUDxe-Sw9BJzP4ehhsX-YcIJcObjpD6eQIRFPeYNJgVlf5WDOlqvzoEHzJf0e6ouZcGpLcZaTTysRWSgSg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Role of AMPKα2 in the phosphorylation of β3 integrin. (A) Effect of AMPK inhibition (compound C [Comp C], 10μM) on the thrombin-induced phosphorylation (p-Tyr747) of β3 integrin in washed human platelets. (B) Thrombin-induced phosphorylation of β3 integrin in platelets from AMPKα2+/+, α2−/−, α1+/+, and α1−/− mice. The bar graphs summarize data from 6 different experiments; *P < .05 and **P < .01 vs solvent (Sol)–treated platelets.
