Parallel phosphorylation of LKB1 and AMPK in thrombin-stimulated human platelets. (A) Concentration-dependent effect of thrombin on the phosphorylation of LKB1 on Thr189. (B) Effect of wortmannin (20nM) on the thrombin-induced phosphorylation of LKB1, AMPK, and ACC. The bar graphs summarize data from 4 independent experiments; *P < .05 and **P < .01 vs solvent (Sol)–stimulated platelets.