Novel/rare fusion genes identified in patients with de novo pediatric AML. (A-D) The structure of the detected fusion proteins. (A) Five RUNX1 rearrangements. (B) Three ETV6 rearrangements. (C) Three NPM1 rearrangements. (D) Other novel gene fusions. R1, R2, and R3 are 51 ± 52 amino acid tandem repeats that comprise the DNA-binding domain Ext–leukemia-associated protein (LAP). 14-3-3 BD, 14-3-3 binding domain; AD, acidic domains; AT-hook, adenine-thymine hook; CCD, coiled-coil domain; CDC15, CDC15 homology region; CID, CBP interaction domain; CtBP, C-terminal binding protein; ETS, ETS domain; FCHD, FER-CIP1 homology domain; HLH, helix-loop-helix; ID, transcription inhibition domain; LiSH, Lis homology domain; MBD, metal-binding domain; MBR, moderately basic region; MTG16, myeloid translocation gene 16; NES, nuclear export signal; NHR2, nervy homology region 2; NLS, nuclear localization signal; PRBR, putative ρ-binding region; RD, runt domain; RHD, runt homolog domain; SH3D, Src homology 3 domain; TAD, transcription activation domain; TAFH, TAF homology; ZF, zinc finger; ZFD, zinc-finger domain; Znf-MYND, MYND zinc-finger domain.