Clinical and genetic profiles of the 369 patients enrolled in the JPLSG AML-05 trial. (A) Pie chart represented the frequency of each gene alterations. (B) Landscape of 369 de novo pediatric AML patients. Each column indicates 1 patient. *^,#Both gene fusions were observed in the same patient. RUNX1-R, RUNX1 rearrangement; NPM1-R, NPM1-rearrangement.