Effect of IFN-α on the gene expression profile of monocyte-derived DCs. (A) Venn diagram showing the numbers of differentially expressed genes in IFN-α DCs and IL-4 DCs with respect to monocytes treated with GM-CSF alone. (B) Signature clusters of the 70 differentially expressed genes in IFN-α DCs compared with the same genes in IL-4 DCs. Yellow and blue colors denote increased and decreased gene expression, respectively, compared with values of common control. (C) Fold increase in the expression of selected up-modulated genes in IFN-α DCs versus control, expressed as CrossLogRatio values. (D) Expression values of selected genes linked to phagocytosis/endocytosis and Ag-processing pathways in IFN-α DCs and IL-4 DCs, expressed as log intensities (error bars indicate SD).