GMI-1070 sustains blood flow rates and prolongs survival in TNF-α–exposed SCD mice challenged by surgical trauma. (A) Blood flow rates were 2-fold higher in GMI-1070–treated SCD mice compared with control SCD mice; ***P < .001. (B) The Kaplan-Meier survival curves for GMI-1070–treated or control SCD mice. Survival was significantly improved in the GMI-1070–treated group. Log-rank (Mantel-Cox) test, P = .007.