GMI-1070 inhibits RBC captures and improves blood flow in SCD mice. (A) Number of RBC interactions with adherent WBCs per minute. Both GMI-1070 and antiselectin antibodies reduced the capture rates of RBCs per adherent leukocytes. (B) The blood flow rates in SCD mice treated with GMI-1070 or anti–P- and –E-selectin antibodies were significantly higher than in mice treated with PBS control. This difference was not due to venular size because the average venular diameter was nearly identical (∼ 21 μm) among the 3 groups (Table 1); ***P < .001.