Leukocyte rolling velocity histograms. Leukocyte rolling velocities in (A) PBS-treated control SCD mice and (B) GMI-1070–treated SCD mice. The arrowheads indicate the means. (C) Overlay of histograms of panels A and B shows the increased average leukocyte velocities in GMI-1070–treated mice. (D) Cumulative frequency histogram of leukocyte rolling velocities for these 2 groups. Median values are indicated by vertical lines; *** P < .001.