Figure 1
![Figure 1. Glycan epitopes and monosaccharide analogs. (A) Putative structure of selectin-binding glycan located at the N-terminus of PSGL-1. This glycan has a terminal tetrasaccharide sLeX epitope and binding sites for DSA and AAL lectins. Neuraminidase cleaves sialic acid (NeuAc) residues to expose the terminal trisaccharide Lewis-X (LeX) epitope. Metabolic inhibition of these glycan structures may reduce leukocyte selectin-binding function. (B) Structure of per-acetylated compounds GalNAc, 4F-GalNAc, 4F-GlcNAc, and [14C]4F-GalNAc.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/115/6/10.1182_blood-2009-07-231480/4/zh89990948290001.jpeg?Expires=1724268601&Signature=zsqjqkCmoZxmB1crpnwcn9AA8oN1Yc8BdTCMCD0-0d6ooLlhyrzCnhqPESZz3ZHV4rdgptYjTPypRQwO3yKJxrmnNSeTPwaN5Whfw1cswyhVXxwRbE4hGFU8zez4pPo1ShsAmag3~x9KNBjcHcWayS-lE0Fqf95Iu6uyDqDx84U~t38iwDgFWY~SSrg18Dm4rkO6HFhlxrd5uDmz-hVhyflnXYHSyKq~adN9vWoKdr4tndFFWdpJpVxbws0OWUm1tzCU2y3v3JSVKHxrPvbcYf8AWA5JcX-3vEsRCZ1OwZA-j9SRMlGfOJAWEaoZKzes2XzlUtQOjt1fJuYu5gnBgg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Glycan epitopes and monosaccharide analogs. (A) Putative structure of selectin-binding glycan located at the N-terminus of PSGL-1. This glycan has a terminal tetrasaccharide sLeX epitope and binding sites for DSA and AAL lectins. Neuraminidase cleaves sialic acid (NeuAc) residues to expose the terminal trisaccharide Lewis-X (LeX) epitope. Metabolic inhibition of these glycan structures may reduce leukocyte selectin-binding function. (B) Structure of per-acetylated compounds GalNAc, 4F-GalNAc, 4F-GlcNAc, and [14C]4F-GalNAc.
