Telomere dysfunction induces alterations in the systemic environment impairing B-cell development. (A-C) Neonatal bones from G3mTerc^−/− or mTerc^+/+ mice were transplanted side-by-side under the left and right kidney capsules of 2- to 3-month-old G3mTerc^−/− or mTerc^+/+ recipient mice (n = 5 per group). The grafted bones were analyzed 9 months after transplantation. (A) Representative FACS profiles and (B-C) bar graphs showing the percentage of (B) B cells and (C) myeloid cells in total bone marrow cells of grafted bones and recipient mice of the indicated genotypes. (D-E) Bone marrow cells (1.5 × 10⁶) from 12-month-old G3mTerc^−/− or mTerc^+/+ mice were transplanted into lethally irradiated 2-month-old mTerc^+/+ recipient mice (n = 6 per group). The bone marrow of recipient mice was analyzed 8 months after transplantation. (D-E) Bar graphs showing percentage of donor-derived (D) B cells and (E) myeloid cells in mTerc^+/+ recipient mice that received transplants of G3mTerc^−/− or mTerc^+/+ bone marrow cells. Error bars represent SD in all panels.