Biclustering of ALL patient samples in the 4 main BCP ALL subtypes according to methylation levels of CpG sites defined by repeated cross-validation supervised learning for multivariate classification. Shown is a “heat-map” of the main BCP ALL subtypes by use of the 60 most informative CpG sites in 40 genes defined by the NSC classifier. The CpG sites are shown in the vertical columns and the ALL samples in the horizontal rows. The color code for the BCP ALL subtypes is shown in the bottom left corner of the figure. High methylation levels are shown in red and low methylation levels in blue, according to the scale bar below the figure.