Refined hierarchical clustering of ALL samples in the HeH and t(12,21) BCP ALL and T-ALL subgroups by methylation profile and analysis of probability of disease relapse. (Left) Dendrograms from divisive (top-down) hierarchical clustering by use of the Euclidean distance between beta values for the 300 selected CpG sites as distance metric. In the dendrogram each individual sample is represented by a black or gray horizontal bar. (Right) Probability of relapse (p-relapse) for the patients in group 1 and group 2 (Gray test). The p-relapse is given on the y-axis and the observation time in months on the x-axis. The P values for the difference in p-relapse between group 1 and group 2 are shown in the panels (Gray test). The total number of different events in the 2 groups of patients with HeH and t(12;21) ALL are shown in supplemental Table 3. The number of events for the patients with T-ALL is given in Table 1.