Inverse correlation between the expressions of Notch receptor and podoplanin in postdevelopmental human cutaneous lymphatics. Human neonatal foreskin sections were stained for Notch1 (A,D,G,J) and CD31 (B) or podoplanin (E,H,K). Merged images are shown (C,F,I,L). (A-C) Arrowhead indicates a CD31-high, Notch-high blood vessel, and arrow points to a CD31-low, Notch-low lymphatic vessel. (D-L) All arrowheads mark Notch-high, podoplanin-low lymphatic vessels, and all arrows indicate Notch-low, podoplanin-high lymphatic vessels. Note the inverse correlation in the expression levels of Notch versus podoplanin in panels I and L. Bars represent 100 μm. Fluorescent images were acquired using a Zeiss microscope with a 63× objective and processed with AxioVision Digital Imaging software.