Cytotoxicity of CD8⁺ T cells. CD8⁺ T cells (effectors) from the BM of MGUS patients (; n = 20) and MM patients (; n = 20) were expanded in vitro in the presence of autologous DCs pulsed either with plasma cell lysates (A-D) or opsonized apoptotic plasma cells (E-H). Targets were ex vivo autologous plasma cells (A,C,E,G) or autologous EBV-transformed B cells previously pulsed with autologous plasma cell lysates (B,D,F,H). Shown is percentage-specific lysis at different effector/target ratios (A,B,E,F) and the inhibition of this lysis by a mAb to HLA class I antigen (C,D,G,H). **P ≤ .005, ***P < .001, Mann-Whitney test.