17-DMAG prolongs survival in a mouse model of CLL. (A) Survival curve for TCL1-SCID mice treated with 10 mg/kg 17-DMAG treatment or vehicle control (n = 10/group). (B) White blood cell count (WBC) in 17-DMAG and vehicle control treated TCL1-SCID mice (n = 20/group). Count is determined at day 55 after initiation of treatment by hematoxylin and eosin-stained peripheral blood smear.