Cellular programs deregulated in NKTCL. Representative molecular pathways differentially expressed in NKTCLs by comparison with either normal NK cells (JAK-STAT in panel A, angiogenesis in panel B, apoptosis in panel E), normal B cells and ABC-DLBCL (NF-κB in panel C), normal NK cells and normal B cells (AKT in panel D), or PTCL, NOS (cytotoxicity in panel F) were illustrated. For each line, green corresponds to the minimal intensity value (min), red corresponds to the maximal intensity value (max), and black corresponds to (min + max)/2. Several genes related to JAK-STAT, angiogenesis, and apoptosis-related pathways are overexpressed in NKTCLs compared with normal NK cells, and genes related to the cytotoxicity-related pathway also are overexpressed in NKTCLs compared with PTCL, NOS. Many genes in the NF-κB and AKT signaling pathways are overexpressed in NKTCLs compared with normal B cells, with a molecular signature similar to that of ABC-DLBCL in NK-κB pathway. The expression data of PDGFRA in NKTCLs, 2 NKTCL-derived cell lines, and normal NK cells is highlighted. T1-7: 7 NKTCL samples; C1-16: 16 PTCL, NOS samples; AcNK, AcNK02, AcNK08, AcNK24: activated NK cells; ReNK, ReNK: resting NK cells; CB.1-8 and CB.11: 9 centroblasts samples; CC.1-8 and CC.11: 9 centrocytes samples; and ABC.2024-2195: 15 ABC-DLBCL samples.