Differential expression of CD49d, CCL3, and CCL4 chemokines in CLL B cells with ongoing IgG CSR and in their IgM counterpart. (A) Flow cytometric analysis from CD49d protein expression in 3 representative patients. Although increased levels of CD49d are found in the UM CLLs, expression values for this protein were always higher in the IgG⁺ subset that in their counterpart IgM⁺ subset. (B) Values are mean (± SE) for MFI of CD49d expression in the 6 patients with CLL with high AID expression levels. (C) Flow cytometric profiles of CD38 expression inside the IgG subset from 3 representative patients with CLL. Numbers in quadrants indicate percentages of cells. (D) CCL3 and CCL4 mRNA profile expressions in the different isolated subsets (IgM⁺ and IgG⁺) from the 3 representative patients with UM CLL.