Figure 2
Evidence of both antibody- and cell-mediated thrombocytopenia. Platelet counts in irradiated SCID mice transferred with (A) 5 × 104 nondepleted splenocytes from CD61 KO mice immunized against WT BALB/c platelets (n = 15) or 5 × 104 splenocytes depleted of either (B) CD4+ T cells (n = 15), (C) CD8+ T cells (n = 18), or (D) CD19+ B cells (n = 14). Data are expressed as in Figure 1. (A,C) Platelet counts could not be determined past day 14 after transfer because of the poor health of the surviving mice. The numbers above the data points are the P values between the observed platelet counts for all mice and the normal mean platelet count. NS indicates not significant.
