Low plasma APC levels in TM^pro mice during endotoxemia. Both TM^pro mice (n = 4) and wild-type (WT, n = 5) mice (6 months old) were sacrificed 6 hours after LPS injection (5 mg/kg, intraperitoneal). Control mice received no injection (n = 4 in each group). The plasma APC levels were determined by immunocapture assay. Data are mean ± SD. *Statistical significance (P < .05). ***Statistical significance (P < .001).