Overall survival plots for sumoylation pathway components. Kaplan-Meier plots represent 6-year overall survival for MM patients treated with high-dose chemotherapy and stem cell transplantation. Plots indicated the survival of those with indicated gene expression either above or below the median. A total of 551 patients were included in the analyses in (A) with UBE2I, (B) with PIAS1, or (C) with ARF. A total of 350 patients were analyzed (D) with 175 patients having expression of both UBE2I and PIAS1 genes above the median and 175 patients below the median.