Figure 6
Treg cells do not require granzyme B to suppress production of GVHD-associated cytokines in vivo. Lethally irradiated (900 cGy) Balb/c mice received 2 × 106 129/SvJ TCD BM cells with or without 4 × 105 129/SvJ CD25− Teff cells (both CD4+ and CD8+) and 4 × 105 wild-type or Gzmb−/− CD4+CD25+ Treg cells. Seven days after transplantation, serum was harvested and analyzed via cytometric bead array for the production of (A) IL-2, (B) IL-4, (C) IL-5, (D) IL-10, (E) granulocyte-macrophage colony-stimulating factor, and (F) interferon-γ. There was no statistically significant difference between groups receiving WT or Gzmb−/− Treg cells.

Treg cells do not require granzyme B to suppress production of GVHD-associated cytokines in vivo. Lethally irradiated (900 cGy) Balb/c mice received 2 × 106 129/SvJ TCD BM cells with or without 4 × 105 129/SvJ CD25− Teff cells (both CD4+ and CD8+) and 4 × 105 wild-type or Gzmb−/− CD4+CD25+ Treg cells. Seven days after transplantation, serum was harvested and analyzed via cytometric bead array for the production of (A) IL-2, (B) IL-4, (C) IL-5, (D) IL-10, (E) granulocyte-macrophage colony-stimulating factor, and (F) interferon-γ. There was no statistically significant difference between groups receiving WT or Gzmb−/− Treg cells.

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