Mice transplanted with Hes1-transduced KSLs, CMPs, and GMPs were kept healthy. (A) Survival curves for mice injected with Hes1-transduced progenitors. No mice showed any signs of MPN for more than 250 days from transplantation. Data were analyzed by the Kaplan-Meier method. The numbers of transplanted mice are shown. Three independent experiments were performed. (B) Survival curves for mice injected with BCR-ABL-transduced progenitors. Mice transplanted with BCR-ABL-transduced KSLs developed fatal MPN within 30 days after transplantation, whereas mice transplanted with BCR-ABL-transduced CMPs or GMPs showed no evidence of disease when killed between 130 and 200 days after transplantation. Data were analyzed using the log-rank test. The 2 independent experiments were performed, and the total numbers of transplanted mice are shown.