Gata1s expression does not lead to leukemia in Tc1 mice. (A) Graphs show mean (± SEM) red blood cell (RBC), white blood cell (WBC), and platelet counts and mean corpuscular volume (MCV) in neonatal mice of the indicated genotypes (n = 12 [Wt, Tc1], n = 8 [Gata1s, Tc1Gata1s]). (B) Graphs show mean (± SEM) RBC, WBC, and platelet counts and MCV as a function of age in mice of the indicated genotypes (n = 10-15). (C) Graph showing mean (± SEM) splenic weights of 15-month-old mice of the indicated genotypes (n = 12 [Wt], n = 7 [Tc1, Gata1s], n = 9 [Tc1Gata1s]). (D-E) Mean (± SEM) frequencies of CFU-MKs, CFU-Es, and CFU-GMs in the liver of (D) e11.5 and (E) e16.5 fetuses of the indicated genotypes (D: n = 8 [Wt, Tc1Gata1s], n = 10 [Tc1], n = 6 [Gata1s]; E: n = 7 [Wt], n = 6 [Tc1], n = 8 [Gata1s], n = 9 [Tc1Gata1s]). In panels A and C through E, significant differences relative to wild-type are indicated: *P < .05, **P < .01, ***P < .001.